Detection of Aneuploidy in Cell Free DNA to Improve the Sensitivity of Diagnostic Peritoneal Lavage in Gastric Cancer
Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Observational
SUMMARY
Aneuploidy may be used as a more sensitive diagnostic tool to detect peritoneal metastasis compared to conventional cytology and imaging techniques. Our aim is to establish whether aneuploidy as detected in cfDNA (as a measure for ctDNA) in PLF of patients with GC may hold value as an additional staging and tumor evaluation method in GC patients.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
View:
• Age ≥18 years old;
• Written informed consent according to the ICH-GCP and national/local regula-tions.
• Operable patients who will undergo a planned diagnostic laparoscopy for a benign indication bariatric or gallbladder disease);
• Age ≥18 years old;
• Written informed consent according to the ICH-GCP and national/local regulations.
Locations
Other Locations
Netherlands
Erasmus MC
RECRUITING
Rotterdam
Contact Information
Primary
Jessie Huizer, Drs.
t.j.huizer@erasmusmc.nl
+31107034523
Backup
Niels Guchelaar
n.guchelaar@erasmusmc.nl
Time Frame
Start Date: 2024-12-17
Estimated Completion Date: 2028-07
Participants
Target number of participants: 63
Treatments
Gastric cancer patients
Operable patients who will undergo DLS for GC. Patients will be identified from the MDT (multidisciplinary tumor board).
non-cancer controls
Patients who will undergo a planned laparoscopy for bariatric or gallbladder disease
Related Therapeutic Areas
Sponsors
Leads: Erasmus Medical Center